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due to gastrointestinal disorders in 0.8% and 1.6% of patients on metformin and not on metformin respectively (p=0.011), and due to malnutrition in 1.5% and 0% of patients on metformin and not on metformin respectively (p=0.484)

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These findings highlighted the interconnected impact of cigarette smoke on lung and gut inflammation, microbiota, and gene expression, suggesting shared mechanisms underlying COPD and intestinal disorders [109]

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